Overview:
Vitamin
B6, also called pyridoxine, is one of 8 B vitamins. All B vitamins help the
body convert food (carbohydrates) into fuel (glucose), which is used to produce
energy. These B vitamins, often referred to as B complex vitamins, also help
the body metabolize fats and protein. B complex vitamins are needed for healthy
skin, hair, eyes, and liver. They also help the nervous system function
properly.
All
B vitamins are water-soluble, meaning that the body does not store them. Vitamin
B6 helps the body make several neurotransmitters, chemicals that carry signals
from one nerve cell to another. It is needed for normal brain development and
function, and helps the body make the hormones serotonin and norepinephrine,
which influence mood, and melatonin, which helps regulate the body clock.
Along
with vitamins B12 and B9 (folic acid), B6 helps control levels of homocysteine
in the blood. Homocysteine is an amino acid that may be associated with heart
disease. Your body needs B6 in order to absorb vitamin B12 and to make red
blood cells and cells of the immune system.
It
is rare to have a significant deficiency of B6, although studies indicate many
people may be mildly deficient, especially children and the elderly. Certain
medications can also cause low levels of B6 in the body. Symptoms of serious
deficiency include muscle weakness, nervousness, irritability, depression,
difficulty concentrating, and short-term memory loss.
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Heart Disease
It
isn' t clear how vitamin B6 might affect heart disease. People who don't get
enough B6 in their diet have a higher risk of heart disease. And B6 plays a
role in lowering levels of homocysteine in the blood. High levels of
homocysteine appear to be associated with heart disease, but scientists don' t
know exactly what the relationship is. They also do not know whether lowering
levels of homocysteine will reduce risk of heart disease. Until more is known,
the best action is to get enough B6 through food, and to take supplements if
your doctor recommends them.
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Nausea and Vomiting during
pregnancy (morning sickness)
Several studies, including one large
double-blind, placebo-controlled study, found that a daily dose of 30 mg of B6
may help reduce morning sickness. However, other studies have found no benefit.
If you are pregnant, be sure to ask your doctor before taking any supplements,
including vitamin B6.
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Age-Related Macular
Degeneration
One large study found that women who
took 500 mg of vitamin B6 daily along with 1,000 mcg of cyanocobalamin (vitamin
B12) and 2,500 mcg of folic acid reduced their risk of developing AMD, an eye
disease that can cause loss of vision.
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Depression
Vitamin B 6 helps your body make
serotonin, a chemical that influences mood. Low levels of serotonin are
associated with depression, and some antidepressant medications work by raising
levels of serotonin. Some researchers think that vitamin B6 might help reduce
symptoms of depression, but there isn' t any real evidence yet. More research
is needed.
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Premenstrual Syndrome (PMS)
Although some studies show that
vitamin B6 may help improve PMS symptoms, most of these studies were poorly
designed. Studies that were well designed found no benefit from B6. Until more
research is done, talk with your doctor about whether using B6 is right for
you. Some people who believe B6 is effective for PMS say it may take up to 3
months to see a noticeable change.
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Carpal Tunnel Syndrome
Some early studies suggested that B6
might help reduce inflammation and symptoms of carpal tunnel syndrome. However,
most of the well-designed studies have found that it is not effective.
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Rheumatoid Arthritis
Low levels of vitamin B6 have been
associated with rheumatoid arthritis. Some studies also suggest that people
with RA may need more vitamin B6 than healthy people because chronic
inflammation may lower B6 levels. Eating a healthy, balanced diet and taking a
multivitamin is a good idea for anyone who has a chronic illness, such as
rheumatoid arthritis. Talk to your doctor before taking B6 supplements.
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Tardive Dyskinesia
A few small studies have found that
vitamin B6 may improve symptoms of tardive dyskinesia compared to placebo.
Tardive dyskinesia is a side effect of some antipsychotic drugs that are taken
for a long while, and involves involuntary movement of muscles, such as in the
tongue, lips, face and jaw, arms, legs, fingers or toes.
Dietary Sources:
Good food sources of vitamin B6
include chicken, turkey, tuna, salmon, shrimp, beef liver, milk, cheese,
lentils, beans, spinach, carrots, brown rice, bran, sunflower seeds, wheat
germ, and whole-grain flour.
Available Forms:
Vitamin B6 can be found in
multivitamins, including children's chewable and liquid drops, B complex
vitamins, or can be sold separately. It is available in a variety of forms,
including tablets, softgels, and lozenges. Vitamin B6 is also sold under the
names pyridoxal, pyridoxamine, pyridoxine hydrochloride, and pyridoxal-5-phosphate.
How to Take It:
People who eat a balanced diet should
meet the daily requirement for vitamin B6 without taking a supplement. As with
all medications and supplements, check with a health care provider before
giving vitamin B6 supplements to a child.
Daily recommendations for dietary
vitamin B6 are listed below.
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Pediatric
·
Infants
0 - 6 months: 0.1 mg (adequate intake)
·
Infants
7 months - 1 year: 0.3 mg (adequate intake)
·
Children
1 - 3 years: 0.5 mg (RDA)
·
Children
4 - 8 years: 0.6 mg (RDA)
·
Children
9 - 13 years: 1 mg (RDA)
·
Boys 14
- 18 years: 1.3 mg (RDA)
·
Girls 14
- 18 years: 1.2 mg (RDA)
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Adult
· 19 - 50 years: 1.3 mg (RDA)
· Men 51 years and older: 1.7 mg (RDA)
· Women 51 years and older: 1.5 mg (RDA)
· Pregnant women: 1.9 mg (RDA)
· Breastfeeding women: 2.0 mg (RDA)
Larger
doses have been used in some studies, but you should not take doses above 100 mg per day without a health
care provider's supervision. Large doses
of B6 may cause nerve damage.
Precautions:
Because of the potential for side
effects and interactions with medications, you should take dietary supplements
only under the supervision of a knowledgeable health care provider.
Very high doses -- 200 mg or more per
day -- of vitamin B6 can cause neurological disorders, such as loss of feeling
in the legs and imbalance. Stopping high doses usually leads to a complete
recovery within 6 months. There have been rare reports of allergic skin
reactions to high doses of vitamin B6 supplements. Other side effects can
include sensitivity to sunlight, nausea, abdominal pain, and loss of appetite.
Possible Interactions:
If you are being treated with any of
the following medications, you should not use vitamin B6 supplements without
first talking to your health care provider.
Drugs that reduce levels of B6 in the
body -- If you take any of these medications, be sure to get enough B6 in your diet:
·
Cycloserine
(Seromycin), used to treat tuberculosis
·
Hydralazine
(Apresoline), used to treat high blood pressure
·
Isoniazid,
used to treat tuberculosis
·
Penicillamine,
used to treat rheumatoid arthritis
·
Theophylline
(TheoDur), used to treat asthma
Antibiotics, Tetracycline -- All B complex vitamins, including vitamin B6, interfere with the
absorption and effectiveness of antibiotic tetracycline. You should take
tetracycline at different times from vitamin B6 and other B vitamins.
Antidepressant Medications -- Taking vitamin B6 supplements may improve the effectiveness of
some tricyclic antidepressants such as nortriptyline (Pamelor), especially in
elderly people. Other tricyclic antidepressants include amitriptyline (Elavil),
desipramine (Norpramin), and imipramine (Tofranil).
On the other hand, antidepressants
called monoamine oxidase inhibitors (MAOIs) may reduce blood levels of vitamin
B6. Examples of MAOIs include phenelzine (Nardil) and tranylcypromine
(Parnate).
Amiodarone (Cordarone) -- This drug, used to treat an irregular heartbeat, makes your skin more
sensitive to sunlight. Taking vitamin B6 along with this drug may increase your
risk of sunburn, blistering, or a rash.
Chemotherapy drugs -- Vitamin B6 may reduce certain side effects of 5-fluorouracil and
doxorubicin, medications used to treat cancer. Talk to your doctor before
taking any supplement if you are undergoing chemotherapy.
Erythropoietin (EPO) -- Erythropoietin therapy, used to treat severe anemia, may
decrease vitamin B6 levels in red blood cells.
Levodopa (L-dopa) -- Vitamin B6 reduces the effectiveness of levodopa, a medication used to treat Parkinson's disease. However, it does not seem to have the same
effect on the combination of levodopa and carbidopa. Your doctor may be able to
determine a dose of B6 that can safely help reduce side effects of levodopa.
Taking vitamin B6 along with levodopa should be done only under your doctor' s
supervision.
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